The park extends towards the South of Ethiopia, on the east bank of the Omo River. The latter river is 1,000 km long and reaches all the way to Lake Turkana in Kenya, of which it is the only affluent.
The park, with its typical African environment, is mostly interesting because of the wide range of peoples that inhabit it, including the Mursi, Karo, Hamer, Banna, Dizi and Bodi.